ABSTRACT
This cases series describes the profile of adult patients with acute promyelocytic leukaemia [APL] at a referral hospital in Qatar of 34 acute myeloid leukaemia [AML] cases diagnosed, 11 [32%] were classified as APL. Disseminated intravascular coagulation was common at presentation [91%]. Severe thrombocytopenia was seen in 73%, leukocytosis in 55% and severe anaemia in 45%. Only 2 patients were of the classic hypergranular type. In the remaining 9 patients, 3 morphological subtypes were recognized: microgranular variant [6 patients], hyperbasophilic [2 patients] and regular nuclear outline M3r [1 patient]. Translocation t[15;17] was detected in 63% of cases. APL constitutes a high proportion of AML cases in Qatar, with considerable morphological heterogeneity and a predominance of APL variants with unfavourable presenting features
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Leukemia, Promyelocytic, Acute/pathology , Leukemia, Promyelocytic, Acute/genetics , Immunophenotyping , CytogeneticsABSTRACT
Lipid-lowering agents such as HMG-CoA reductase inhibitors [also known as statin drugs] are generally well tolerated. But a recognized side effect still can happen, We report a case of 47-year-old Iraqi male patient previously known hypothyroid, was not on replacement therapy, as he did not appear after his thyroid functions was checked came in with severe body pain for 10 months got worse in the last three months, started on lipostat [ten months ago] found to have myopathy as evident by high CPK which improved gradually clinically and biochemical after stopping lipostat
Subject(s)
Humans , Male , Pravastatin , Muscular Diseases/etiology , Hydroxymethylglutaryl-CoA Reductase Inhibitors , Hypolipidemic Agents , Creatine Kinase , Muscular Diseases/chemically inducedABSTRACT
Thyroid associated opthalmopathy [TAO] may precede, coincide, or follow the systemic complications of dysthyroidism it can present gradually as dry eyes, puffy eyelids, ocular pressure or pain, field loss, diplopia with 3rd, 4th, 6th nerve palsies we report a 22 year old Filipina female who presented with sudden onset of diplopia, pain, headache, with no sign or symptom of dysthyroidism and clinically sounds to have 3rd, 4th, and 6th, nerve palsies [left eye] the case represents diagnostic dilemma that's why found it worth to be reported